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--- inherit-mental-illness [2024/01/25 23:15] – yiler.huang
+++ inherit-mental-illness [2024/01/31 02:28] (current) – scott.chen
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-====== Genetics 08: Can You Inherit a Mental Illness? ======
+<html>
+<h1 class="sectionedit1 page-header pb-3 mb-4 mt-5" id="welcome_歡迎蒞臨">Genetics 08: Can You Inherit a Mental Illness?<br>遺傳學 08: 精神疾病會遺傳?<a class="anchorjs-link " href="#welcome_歡迎蒞臨" aria-label="Anchor link for: welcome_歡迎蒞臨" data-anchorjs-icon="" style="font-family: anchorjs-icons; font-style: normal; font-variant: normal; font-weight: normal; line-height: 1; padding-left: 0.375em;"></a></h1>
+</html>
 ===== Yiler =====
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 {{::yiler-science-reading-infographic-8.png?1200|}}
+==== Sources ====
+https://www.nimh.nih.gov/health/topics/anxiety-disorders
+===== Steve =====
+==== Article A ====
+It has been long know that mental health issues can be passed down to next of kin but it is still unknown whether candidate genes are associated with multiple disorders via pleiotropic mechanisms, and/or if other genes are specific to susceptibility for individual disorders. To find out, 157 studies or 1519 meta-analyses of multiple gene and/or multiple disorders were reviewed for genotypes implicated in serious mental disorders that have varying levels of reported heritability. 134 genes were comfirmed to have significant effects cross disorders like major depressive disorder (MDD), anxiety disorders (AD), including panic disorder and obsessive compulsive disorder), schizophrenia (SZ) and bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). the majority (63%, n ¼ 966) focused on identifying genes in schizophrenia, of which 199 meta-analyses confirmed a significant gene effect for 50 genes (97 variants). The next disorder of focus was bipolar disorder at 17% (n ¼ 259 meta-analyses) with 98 meta-analyses confirming 46 genes (65 variants); then MDD at 12% (n ¼ 177 meta-analyses) with 43 meta-analyses confirming 27 genes (27 variants); then ADHD at 5% (n ¼ 81) with 25 meta-analyses confirming 8 genes (11 variants); and finally anxiety disorders at 3% (n ¼ 36) with 13 meta-analyses confirming 3 genes (6 variants).
+==== Article B ====
+Research has found that mental illness likely has a genetic component, but it is most likely caused by a combination of genetic and environmental components. Mental and behavioural conditions that are more likely to have a genetic component includes autism, bipolar disorder, ADHD, major depression, and schizophrenia. There is no genetic test available to determine if a person carries a gene that would give them a higher risk of mental illnesses. The only way to understand their genetic risk of a person developing a mental illness is to look at familial lines. Genetics alone are not the only causes of mental illnesses, other factors such as stress can also lead to mental illnesses.
+==== Infographic ====
+{{ :steve-genes-related-to-mental-illness-plain-svg.svg |}}
+==== Sources ====
+https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Specific+and+common+genes+implicated+across+major+mental+disorders%3A+A+review+of+meta-analysis+studies&btnG=